Yawancin bincike a cikin shekaru goma da suka gabata sun yi nuni da cewa magungunan kashe qwari sune sanadin cutar Parkinson, wanda ke haifar da cututtukan neurodegenerative wanda ke dagula aikin mota kuma yana addabar Amurkawa miliyan daya.Duk da haka, masana kimiyya har yanzu ba su da kyakkyawar fahimtar yadda waɗannan sinadarai ke lalata kwakwalwa.Wani bincike na baya-bayan nan yana ba da amsa mai yiwuwa: magungunan kashe qwari na iya hana hanyoyin sinadarai waɗanda galibi ke kare ƙwayoyin cuta na dopaminergic, waɗanda ƙwayoyin kwakwalwa ne waɗanda cututtukan ke kaiwa hari.Nazarin farko ya kuma nuna cewa wannan tsarin zai iya taka rawa a cikin cutar Parkinson ko da ba tare da amfani da magungunan kashe qwari ba, yana ba da sabbin abubuwa masu ban sha'awa don haɓaka ƙwayoyi.
Binciken da aka yi a baya ya nuna cewa maganin kashe kwari da ake kira benomyl, ko da yake an hana shi a Amurka saboda matsalolin kiwon lafiya a 2001, har yanzu yana daɗe a cikin muhalli.Yana hana aldehyde dehydrogenase a cikin hanta (ALDH) ayyukan sinadarai.Masu bincike a Jami'ar California, Los Angeles, Jami'ar California, Berkeley, Cibiyar Fasaha ta California, da Cibiyar Kiwon Lafiyar Tsohon Soja ta Greater Los Angeles sun so su san ko wannan maganin kashe kwari zai kuma shafi matakin ALDH a cikin kwakwalwa.Aikin ALDH shine ya lalata sinadari mai guba DOPAL da ke faruwa a zahiri don mai da shi mara lahani.
Don ganowa, masu binciken sun fallasa nau'ikan ƙwayoyin kwakwalwar ɗan adam daban-daban daga baya gabaɗayan zebrafish zuwa benomyl.Jagoran marubucin su kuma masanin ilimin halittar jiki na Jami'ar California, Los Angeles (UCLA) Jeff Bronstein (Jeff Bronstein) ya bayyana cewa sun gano cewa "ya kashe kusan rabin kwayoyin cutar dopamine, yayin da duk sauran kwayoyin cutar ba a gwada su ba.""Lokacin da suka yi watsi da kwayoyin da abin ya shafa, sun tabbatar da cewa benomyl ya hana ayyukan ALDH, ta haka yana kara kuzarin tarin DOPAL mai guba.Abin sha'awa shine, lokacin da masana kimiyya suka yi amfani da wata dabara don rage matakan DOPAL, benomyl bai cutar da neurons na dopamine ba.Wannan binciken ya nuna cewa maganin kashe kwari yana kashe waɗannan ƙwayoyin cuta musamman saboda yana ba DOPAL damar tarawa.
Tun da sauran magungunan kashe qwari kuma suna hana ayyukan ALDH, Bronstein yayi hasashen cewa wannan tsarin zai iya taimakawa wajen bayyana alaƙa tsakanin cutar Parkinson da magungunan kashe qwari.Mafi mahimmanci, bincike ya gano cewa ayyukan DOPAL yana da yawa a cikin kwakwalwar masu cutar Parkinson.Waɗannan majiyyatan ba su kasance masu kamuwa da magungunan kashe qwari ba sosai.Saboda haka, ba tare da la'akari da dalilin ba, wannan tsari na cascade na biochemical na iya shiga cikin tsarin cutar.Idan wannan gaskiya ne, to, magungunan da ke toshewa ko share DOPAL a cikin kwakwalwa na iya tabbatar da zama magani mai ban sha'awa ga cutar Parkinson.