Ua hōʻike ʻia nā haʻawina he nui i nā makahiki he ʻumi i hala aku nei ʻo nā pesticides ke kumu kumu o ka maʻi o Parkinson, ʻo ia ka maʻi neurodegenerative e hoʻopilikia i ka hana kaʻa a hoʻopilikia i hoʻokahi miliona ʻAmelika.Eia nō naʻe, ʻaʻole maopopo i ka poʻe ʻepekema pehea e hōʻino ai kēia mau mea kemika i ka lolo.Hōʻike ʻia kahi noiʻi hou i kahi pane hiki: hiki i nā pesticides ke kāohi i nā ala biochemical e pale mau ai i nā neurons dopaminergic, ʻo ia hoʻi nā pūpū lolo i koho ʻia e nā maʻi.Ua hōʻike pū ʻia nā haʻawina mua e hiki ke hana i kēia ala i ka maʻi o Parkinson me ka ʻole o ka hoʻohana ʻana i nā lāʻau pesticides, e hāʻawi ana i nā pahuhopu hoihoi hou no ka hoʻomohala ʻana i ka lāʻau.
Ua hōʻike ʻia nā haʻawina i hala aku nei he pesticide i kapa ʻia he benomyl, ʻoiai ua pāpā ʻia ma ʻAmelika Hui Pū ʻIa no nā pilikia olakino i ka makahiki 2001, e mau ana i loko o ke kaiapuni.Kāohi ia i ka hana kemika aldehyde dehydrogenase i loko o ke ake (ALDH).Ua makemake nā mea noiʻi ma ke Kulanui o Kaleponi, Los Angeles, University of California, Berkeley, California Institute of Technology, a me ka Veterans Affairs Medical Center o Greater Los Angeles e ʻike inā pili pū kēia pesticide i ke kiʻekiʻe o ka ALDH ma ka lolo.ʻO ka hana a ALDH ka hoʻoheheʻe ʻana i ka DOPAL meaʻawaʻawa kūlohelohe i mea e hoʻopōʻino ai.
No ka ʻike ʻana, ua hōʻike nā mea noiʻi i nā ʻano ʻano like ʻole o ka lolo o ke kanaka a ma hope o ka zebrafish holoʻokoʻa i ka benomyl.ʻO kā lākou mea kākau alakaʻi a me ke Kulanui o Kaleponi, Los Angeles (UCLA) neurologist Jeff Bronstein (Jeff Bronstein) i ʻōlelo ua ʻike lākou ua "pepehi i ka hapalua o nā neurons dopamine, ʻoiai ʻaʻole i hoʻāʻo ʻia nā neurons ʻē aʻe.""I ka wā i hoʻopaʻa ʻia ai lākou i nā cell i hoʻopilikia ʻia, ua hōʻoia lākou ua pale maoli ka benomyl i ka hana o ALDH, a laila e hoʻoulu ai i ka hōʻiliʻili ʻona o DOPAL.ʻO ka mea mahalo, i ka wā i hoʻohana ai nā ʻepekema i kahi ʻenehana ʻē aʻe e hōʻemi i nā pae DOPAL, ʻaʻole i hōʻeha ʻo benomyl i nā neurons dopamine.Hōʻike kēia ʻike e pepehi pono ka pesticide i kēia mau neurons no ka mea hiki iā DOPAL ke hōʻiliʻili.
Ma muli o ka pale ʻana o nā pesticides ʻē aʻe i ka hana a ALDH, manaʻo ʻo Bronstein e hiki i kēia ala ke kōkua i ka wehewehe ʻana i ka pilina ma waena o ka maʻi o Parkinson a me nā pesticides maʻamau.ʻO ka mea nui, ua ʻike nā haʻawina he kiʻekiʻe loa ka hana DOPAL i ka lolo o nā maʻi maʻi Parkinson.ʻAʻole i ʻike nui ʻia kēia mau maʻi i nā pesticides.No laila, me ka nānā ʻole i ke kumu, hiki i kēia kaʻina cascade biochemical ke komo i ke kaʻina maʻi.Inā he ʻoiaʻiʻo kēia, a laila hiki ke hōʻoia i nā lāʻau lapaʻau e ālai a hoʻomaʻemaʻe paha i ka DOPAL i loko o ka lolo he lāʻau maikaʻi loa ia no ka maʻi o Parkinson.