Zvidzidzo zvakawanda mumakore gumi apfuura zvakaratidza kuti mishonga yezvipembenene ndiyo honzeri yechirwere cheParkinson, chinova chirwere chetsinga chinokanganisa kushanda kwemotokari uye chinobata miriyoni imwe chete yekuAmerica.Zvisinei, masayendisiti haasati ava kunyatsonzwisisa kuti makemikari aya anokuvadza sei uropi.Ongororo ichangoburwa inoratidza mhinduro inogoneka: mishonga yezvipembenene inogona kuvharidzira nzira dzebiochemical dzinowanzo chengetedza dopaminergic neurons, iwo masero europi anosarudzwa nezvirwere.Zvidzidzo zvekutanga zvakaratidzawo kuti nzira iyi inogona kuita basa muchirwere cheParkinson kunyangwe pasina kushandisa mishonga yekuuraya zvipembenene, ichipa zvinangwa zvitsva zvinonakidza zvekuvandudza zvinodhaka.
Ongororo dzakapfuura dzakaratidza kuti mushonga wezvipembenene unonzi benomyl, kunyangwe wakarambidzwa muUnited States nekuda kwehutano muna 2001, uchiri mumhepo.Inodzivisa aldehyde dehydrogenase muchiropa (ALDH) kemikari basa.Vatsvagiri vepaYunivhesiti yeCalifornia, Los Angeles, University of California, Berkeley, California Institute of Technology, uye Veterans Affairs Medical Center yeGreater Los Angeles vaida kuziva kana mushonga uyu ungakanganisawo mwero weALDH muuropi.Basa reALDH nderekuodza kemikari ine chepfu inongoitika DOPAL kuti isakuvadze.
Kuti uzive, vaongorori vakafumura marudzi akasiyana ehuropi hwemunhu uye gare gare zebrafish yese kune benomyl.Munyori wavo anotungamira uye University of California, Los Angeles (UCLA) chiremba wetsinga Jeff Bronstein (Jeff Bronstein) akataura kuti vakawana kuti "yakauraya inenge hafu ye dopamine neurons, nepo dzimwe neuroni dzese dzisina kuongororwa.""Pavakatsvedza pamaseru akakanganisika, vakasimbisa kuti benomyl yakavharisa basa reALDH, nekudaro ichikurudzira kuunganidzwa kwehupfu yeDOPAL.Sezvineiwo, apo masayendisiti akashandisa imwe nzira kuderedza DOPAL mazinga, benomyl haina kukuvadza dopamine neurons.Kuwana uku kunoratidza kuti mushonga wezvipembenene unouraya ma neuron aya nekuti unobvumidza DOPAL kuungana.
Sezvo mamwe mishonga yezvipembenene ichidzivisawo basa reALDH, Bronstein anofungidzira kuti nzira iyi inogona kubatsira kutsanangura kubatana pakati pehosha yeParkinson nemishonga inouraya zvipembenene.Zvinotonyanya kukosha, zvidzidzo zvakawana kuti DOPAL chiitiko chakakwira zvakanyanya muhuropi hwevarwere veParkinson's disease.Varwere ava havana kunyanya kubatwa nemishonga yezvipembenene.Naizvozvo, zvisinei nechikonzero, iyi biochemical cascade process inogona kutora chikamu muhurongwa hwechirwere.Kana ichi chiri chokwadi, saka mishonga inovhara kana kubvisa DOPAL muuropi inogona kuratidza kuva inovimbisa kurapwa kwechirwere cheParkinson.