Ntau qhov kev tshawb fawb nyob rau hauv kaum xyoo dhau los tau taw qhia tias cov tshuaj tua kab yog qhov ua rau tus kab mob Parkinson, uas yog cov kab mob neurodegenerative uas ua rau lub cev tsis muaj zog thiab cuam tshuam rau ib lab tus neeg Asmeskas.Txawm li cas los xij, cov kws tshawb fawb tseem tsis tau muaj kev nkag siab zoo txog cov tshuaj no ua rau lub hlwb puas.Ib txoj kev tshawb fawb tsis ntev los no qhia txog cov lus teb tau: tshuaj tua kab tuaj yeem cuam tshuam txoj hauv kev biochemical uas ib txwm tiv thaiv dopaminergic neurons, uas yog lub hlwb hlwb uas xaiv los ntawm cov kab mob.Cov kev tshawb fawb ua ntej kuj tau qhia tias txoj hauv kev no tuaj yeem ua lub luag haujlwm hauv Parkinson tus kab mob txawm tias tsis siv tshuaj tua kab, muab lub hom phiaj tshiab rau kev txhim kho tshuaj.
Cov kev tshawb fawb yav dhau los tau pom tias cov tshuaj tua kab hu ua benomyl, txawm tias nws raug txwv hauv Tebchaws Meskas rau kev txhawj xeeb txog kev noj qab haus huv hauv xyoo 2001, tseem nyob hauv ib puag ncig.Nws inhibits aldehyde dehydrogenase hauv daim siab (ALDH) tshuaj ua haujlwm.Cov kws tshawb fawb ntawm University of California, Los Angeles, University of California, Berkeley, California Institute of Technology, thiab Veterans Affairs Medical Center ntawm Greater Los Angeles xav paub seb cov tshuaj tua kab no puas yuav cuam tshuam rau qib ALDH hauv lub hlwb.ALDH txoj haujlwm yog txhawm rau rhuav tshem cov tshuaj lom DOPAL uas tshwm sim los ua kom tsis muaj mob.
Txhawm rau kom paub, cov kws tshawb fawb tau nthuav tawm ntau hom tib neeg lub hlwb thiab tom qab ntawd tag nrho zebrafish rau benomyl.Lawv tus thawj coj sau ntawv thiab University of California, Los Angeles (UCLA) neurologist Jeff Bronstein (Jeff Bronstein) tau hais tias lawv pom tias nws "tua yuav luag ib nrab ntawm dopamine neurons, thaum tag nrho lwm cov neurons tsis tau kuaj.""Thaum lawv zeroed ntawm cov hlwb cuam tshuam, lawv tau lees paub tias benomyl tiag tiag inhibited cov haujlwm ntawm ALDH, yog li txhawb nqa cov tshuaj lom ntawm DOPAL.Interestingly, thaum cov kws tshawb fawb siv lwm cov txheej txheem los txo DOPAL qib, benomyl tsis ua mob rau dopamine neurons.Qhov kev tshawb pom no qhia tau hais tias cov tshuaj tua kab tshwj xeeb tua cov neurons vim nws tso cai rau DOPAL khaws cia.
Txij li lwm cov tshuaj tua kab kuj inhibit qhov kev ua ntawm ALDH, Bronstein xav tias txoj hauv kev no tuaj yeem pab piav qhia txog kev sib txuas ntawm Parkinson tus kab mob thiab tshuaj tua kab.Qhov tseem ceeb tshaj, kev tshawb fawb tau pom tias DOPAL kev ua haujlwm siab heev hauv lub hlwb ntawm cov neeg mob Parkinson tus kab mob.Cov neeg mob no tsis tau raug tshuaj tua kab ntau heev.Yog li, tsis hais qhov ua rau, qhov txheej txheem biochemical cascade no tuaj yeem koom nrog cov txheej txheem kab mob.Yog tias qhov no muaj tseeb, cov tshuaj uas thaiv lossis tshem tawm DOPAL hauv lub hlwb tuaj yeem ua pov thawj tias yog kev kho mob rau Parkinson tus kab mob.