Uphononongo oluninzi kule minyaka ilishumi idlulileyo luye lwabonisa ukuba amayeza okubulala izitshabalalisi ngoyena nobangela wesifo sikaParkinson, esisisifo se-neurodeergenerative esiphazamisa ukusebenza kweemoto kwaye sithwaxa izigidi zabantu baseMelika.Noko ke, izazinzulu azikayiqondi kakuhle indlela le michiza eyonakalisa ngayo ingqondo.Uphononongo lwakutsha nje lucebisa impendulo enokubakho: izibulali-zinambuzane zinokunqanda iindlela ze-biochemical ezihlala zikhusela i-dopaminergic neurons, iiseli zengqondo ezihlaselwe ngokukhethiweyo zizifo.Uphononongo lokuqala lukwabonise ukuba le ndlela inokudlala indima kwisifo sikaParkinson nangaphandle kokusetyenziswa kwezibulali zinambuzane, ibonelela ngeethagethi ezintsha ezinomdla kuphuhliso lwamachiza.
Uphononongo oludlulileyo lubonise ukuba isibulali-zinambuzane esibizwa ngokuba yi-benomyl, nangona sasivaliwe e-United States ngenxa yeenkxalabo zempilo ngo-2001, sisahleli kwimo engqongileyo.Ithintela i-aldehyde dehydrogenase kwisibindi (ALDH) umsebenzi weekhemikhali.Abaphandi kwiYunivesithi yaseCalifornia, eLos Angeles, kwiYunivesithi yaseCalifornia, eBerkeley, eCalifornia Institute of Technology, kunye ne-Veterans Affairs Medical Centre ye-Greater Los Angeles bafuna ukwazi ukuba le pesticide iya kuchaphazela izinga le-ALDH kwingqondo.Umsebenzi we-ALDH kukubolisa imichiza eyityhefu evela ngokwendalo ethi DOPAL ukuze ingabi nabungozi.
Ukufumanisa, abaphandi baveze iintlobo ezahlukeneyo zeeseli zengqondo yomntu kwaye kamva i-zebrafish epheleleyo kwi-benomyl.Umbhali wabo okhokelayo kunye neYunivesithi yaseCalifornia, eLos Angeles (UCLA) ugqirha wemithambo-luvo uJeff Bronstein (uJeff Bronstein) wathi bafumanise ukuba "ibulale phantse isiqingatha se-dopamine neurons, ngelixa zonke ezinye ii-neuron zingavavanywanga."“Xa bangena kwiiseli ezichaphazelekayo, baqinisekisa ukuba ngenene i-benomyl iwuthintele umsebenzi we-ALDH, ngaloo ndlela ivuselela ukuqokelelana okunetyhefu kwe-DOPAL.Okubangel 'umdla kukuba, xa izazinzulu zisebenzisa enye indlela yokunciphisa amanqanaba e-DOPAL, i-benomyl ayizange yenzakalise i-dopamine neurons.Oku kufunyaniswayo kuphakamisa ukuba i-pesticide ibulala ngokukodwa ezi neurons kuba ivumela i-DOPAL ukuba iqokelele.
Ekubeni ezinye ii-pesticides nazo zivimbela umsebenzi we-ALDH, i-Bronstein iqikelela ukuba le ndlela inokunceda ukucacisa ikhonkco phakathi kwesifo sika-Parkinson kunye ne-pesticides jikelele.Okubaluleke ngakumbi, uphando lufumanise ukuba umsebenzi we-DOPAL uphezulu kakhulu kwiingqondo zezigulane ze-Parkinson's disease.Ezi zigulana azikhange zibe sesichengeni kakhulu kwizibulali-zinambuzane.Ngoko ke, kungakhathaliseki ukuba yintoni isizathu, le nkqubo ye-biochemical cascade inokuthatha inxaxheba kwinkqubo yesifo.Ukuba oku kuyinyani, ngoko ke amayeza avala okanye asusa i-DOPAL ebuchosheni anokubonisa ukuba lunyango oluthembisayo lwesifo sikaParkinson.