Ucwaningo oluningi kule minyaka eyishumi edlule luveze ukuthi izibulala-zinambuzane ziyimbangela eyinhloko yesifo sika-Parkinson, okuyisifo se-neurodegenerative esiphazamisa ukusebenza kwezimoto futhi sihlasele abantu baseMelika abayisigidi.Nokho, ososayensi abakaqondi kahle ukuthi la makhemikhali alimaza kanjani ubuchopho.Ucwaningo lwakamuva luphakamisa impendulo engaba khona: izibulala-zinambuzane zingase zivimbele izindlela ze-biochemical ezivame ukuvikela ama-neurons e-dopaminergic, okungamangqamuzana obuchopho ahlaselwa izifo ngokukhetha.Ucwaningo lokuqala luye lwabonisa nokuthi le ndlela ingabamba iqhaza esifweni sika-Parkinson ngisho nangaphandle kokusetshenziswa kwezibulala-zinambuzane, okuhlinzeka ngezinhloso ezintsha ezijabulisayo zokuthuthukiswa kwezidakamizwa.
Ucwaningo lwangaphambilini lubonise ukuthi isibulala-zinambuzane esibizwa ngokuthi i-benomyl, nakuba savalwa e-United States ngenxa yezinkinga zempilo ngo-2001, sisekhona endaweni ezungezile.Ivimbela ukusebenza kwamakhemikhali e-aldehyde dehydrogenase esibindini (ALDH).Abacwaningi baseNyuvesi yaseCalifornia, eLos Angeles, eNyuvesi yaseCalifornia, eBerkeley, eCalifornia Institute of Technology, naseVeterans Affairs Medical Center yaseGreater Los Angeles bafuna ukwazi ukuthi lesi sibulala-zinambuzane sizolithinta yini izinga le-ALDH ebuchosheni.Umsebenzi we-ALDH ukubola ikhemikhali enobuthi eyenzeka ngokwemvelo i-DOPAL ukuze ingabi yingozi.
Ukuthola lokho, abacwaningi badalula izinhlobo ezahlukene zamangqamuzana obuchopho bomuntu futhi kamuva ne-zebrafish yonke ku-benomyl.Umbhali wabo oholayo kanye nodokotela we-neurologist wase-University of California, e-Los Angeles (UCLA) uJeff Bronstein (Jeff Bronstein) uthe bathole ukuthi “kubulale cishe ingxenye yama-dopamine neurons, kuyilapho wonke amanye ama-neurons engahlolwanga.”“Lapho iqanda kumaseli athintekile, yaqinisekisa ukuthi i-benomyl ivimbele ngempela umsebenzi we-ALDH, ngaleyo ndlela ivuse ukunqwabelana okunobuthi kwe-DOPAL.Kuyathakazelisa ukuthi lapho ososayensi basebenzisa enye indlela yokunciphisa amazinga e-DOPAL, i-benomyl ayizange ilimaze ama-dopamine neurons.Lokhu okutholakele kusikisela ukuthi isibulala-zinambuzane siwabulala ngokuqondile la ma-neuron ngoba sivumela i-DOPAL ukuthi iqongelele.
Njengoba ezinye izibulala-zinambuzane nazo zivimbela umsebenzi we-ALDH, uBronstein uqagela ukuthi le ndlela ingasiza ekuchazeni ukuxhumana phakathi kwesifo sikaParkinson nezibulala-zinambuzane ezivamile.Okubaluleke nakakhulu, ucwaningo luthole ukuthi umsebenzi we-DOPAL uphezulu kakhulu ebuchosheni beziguli ze-Parkinson's disease.Lezi ziguli azizange zichayeke kakhulu emithini yokubulala izinambuzane.Ngakho-ke, kungakhathaliseki ukuthi iyini imbangela, le nqubo ye-biochemical cascade ingase ibambe iqhaza enqubweni yesifo.Uma lokhu kuyiqiniso, khona-ke izidakamizwa ezivimba noma ezisula i-DOPAL ebuchosheni zingase zibe ukwelapha okuthembisayo kwesifo sika-Parkinson.